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Triggers of hair cell regeneration in the avian inner ear
Authors:Hideo Yamane  Takayuki Nakagawa  Hiroyoshi Iguchi  Shigetarou Shibata  Masahiro Takayama  Kishiko Sunami  Yoshiaki Nakai
Affiliation:Department of Otolaryngology, Osaka City University Medical Schoo 1-5-7, Asahimachi Abenoku, Osaka 545, Japan
Abstract:
We performed an in vitro study in order to determine possible triggers of hair cell regeneration in the chick basilar papilla following degeneration. We compared the response of sensory epithelium damaged by collagenase treatment with that damaged by acoustic trauma. The former exhibited no proliferative activity, but the latter did. The basilar papillae damaged by acoustic trauma could have proliferating activity in medium containing fetal bovine serum (FBS) or epidermal growth factor (EGF) but not in the medium without FBS or EGF. These findings indicate that regeneration of basilar papillae depends on the manner of cell death and that FBS or EGF is required for regeneration.
Keywords:Chick   Basilar papilla   Sound exposure   Regeneration   Epidermal growth factor   BrdU
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