卡托普利在L-NAME高血压大鼠中的作用

目的探讨卡托普利在Ｎω－硝基－Ｌ－精氨酸甲酯（Ｌ－ＮＡＭＥ）高血压大鼠中的作用。方法雄性ＳＤ大鼠口服Ｌ－ＮＡＭＥ四周后，测量动脉血压，并取其主动脉进行离体血管环实验。结果用ＮＯＳ抑制剂长期抑制大鼠体内ＮＯ的产生，可引起血压升高，心肌肥厚，主动脉依赖内皮的血管舒张作用减小。如同时服用卡托普利作抗高血压治疗，可防止心肌肥厚，减弱血压的升高，使由Ｌ－ＮＡＭＥ引起的血管内皮机能失调得到改善。结论卡托普利可通过不依赖一氧化氮的机制，改善Ｌ－ＮＡＭＥ高血压大鼠的心血管机能。

Role of captopril in L-NAME hypertensive rats

Objective To investigate the role of captopril in L-NAME hypertensive rats. Methods Nitric oxide was inhibited in male Spragrue-Dawley rats by oral administration of L-NAME for 4 weeks,mean arterial pressure was measured,isometric tension changes of aortic rings were recorded. Results Chronic inhibition of nitric oxide synthesis by L-NAME results in increase in mean arterial pressure,cardiac hypertrophy and reduction in endothelium-dependent relaxations to acetylcholine.Antihypertensive treatment with captopril prevented L-NAME hypertensive rats from cardiac hypetrophy,significantly reduced blood pressure,partially reversed the vascular endothelial dysfunction. Conclusion Captopril improves cardiovascular function by a mechansim independent of nitric oxide.