血栓性血小板减少性紫癜8例临床分析

目的：探讨血栓性血小板减少性紫癜（TTP）的临床特点和疗效。方法：1996年以前，5／8例应用泼尼松，肝素，双嘧达莫等治疗，仅1例缓解，4例死亡，1997年后，3／8例采用血浆置换（PE）加泼尼松，肝素，双嘧达莫等治疗，3例缓解，结果：随访1－3年，2例健康，1例复发，死于肾功能衰竭。结论：TTP为多系统损伤的严重疾病，PE是TTP的首选治疗。

Clinical analysis of 8 cases of thrombotic thrombocytopenic purpura

Objective:To investigate clinical features and therapeutic efficiency in patients with thrombotic thromcytopenic purpura(TTP).Method:TTP patients diagnosed in our hospital during January 1979 and December 1998 were retrospectively analyzed including clinical demonstration,laboratory findings and treatment. Result:Eight patients are 4 males and 4 females with a median age 34 years. All these 8 patients with TTP were characterized by severe thrombocytopenia, microangiopathic hemolytic anemia, neurologic abnormalities, fever and renal involvement proteinuria,hematuria and azotemia. Treatment:before 1996, 5/8 patients received prednisone,heparin, aspirin and dipyridamole,only one case had obvious effect,4 cases died.After 1997,3/8 patients received plasma exchange (PE),prednisone,heparin and dipyridamole. All 3 patients were CR. Three patients were followed up 1~3 years,2 patients were good,no patient relapsed and died from renal function failure. Conclusion:TTP is a severe disease associated with injuring of multiple organism. PE is the best among the therapeutic methods,to treatment of TTP.