TGF-β_1和MPO在结肠肿瘤中的表达及意义

目的探讨TGF-β1和MPO在人结肠癌组织中的表达及其意义。方法通过免疫组织化学染色法检测53例结肠癌组织,32例结肠腺瘤组织及10例癌旁结肠组织中TGF-β1和MPO的表达及其相互关系。结果TGF-β1和MPO阳性表达在结肠癌组织中为（62.26%,69.81%）均显著性高于癌旁结肠组织（10%,10%）和结肠腺瘤组织（15.63%,21.88%）,差异均有统计学意义（P〈0.05）。TGF-β1和MPO在淋巴结转移组的阳性率（78.57%,85.71%）高于无淋巴结转移组（44.0%,52.0%）,差异均有统计学意义（P〈0.05）。TGF-β1和MPO在结肠癌组织中表达有相关性（r=0.6528,P〈0.05）。结论TGF-β1和MPO可能参与了肿瘤生长和发展的共同通道,在大肠癌的发生、发展和转移过程中起着重要作用。

Expression of TGF-

Objective To explore the expression of TGF-β1 and MPO in human colon cancer tissues. Methods The expressions of TGF-β1 and MPO in colon tissue specimens were determined by immunohistochemistry （two step method） in 53 cases of human colon adenocarcinomas,32 colon adenomas and 10 colon adjacent to adenocarcinomas. Resuits The positive rates of TGF-β1 and MPO in the adenocarcinomas,adenomas and colon adjacent to adenocricinomas were 62.26 % , 15.63 % , 10% ; 69.81% , 10% ,21.88 % , respectively, expression of TGF-β1 and MPO in the adenocarcinomas were higher than that in colon adjacent to adenocarcinomas and colon adenomas （P 〈 0.05） ,Cancer with lymph node metastasis showed significantly higher positive staining rate than those without nodal involvement（P 〈 0.05 ） , there was correlation between TGF-β1 and MPO （r = 0. 6528 ,P 〈 0.05）. Conclusion TGF-β1 and MPO take place in common pathways in tumor development, progression and metastasis. And they play an important role in colorectal carcinomas.