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Isolation and identification of a cis-C8-diol-ester of okadaic acid from Dinophysis acuta in New Zealand. |
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| Authors: | Christopher O Miles Alistair L Wilkins Allan D Hawkes Dwayne J Jensen Janine M Cooney Kristofer Larsen Dirk Petersen Frode Rise Veronica Beuzenberg A Lincoln Mackenzie |
| Affiliation: | AgResearch Ltd., Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand. chris.miles@agresearch.co.nz |
| Abstract: | A cis-isomer of a C(8)-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compound was identified by NMR spectroscopic and liquid chromatography-mass spectrometry (LC-MS) studies, and is the first reported cis-isomer of an okadaic acid C(8)-diol-ester identified in Dinophysis. The more abundant trans-C(8)-diol ester of okadaic acid (2) isolated from the same Dinophysis extract was rapidly hydrolyzed to okadaic acid in vitro by the supernatant from green-lipped mussel hepatopancreas. |
| Keywords: | Okadaic acid Diol ester Dinophysis Hydrolysis Metabolism NMR LC-MS |
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