国产雷帕霉素洗脱支架在急性ST段抬高型心肌梗死中的应用

目的：评价国产雷帕霉素支架在急性ST段抬高型心肌梗死中应用的安全性和有效性，并观察其近、中期临床疗效。方法：将147例急性ST段抬高型心肌梗死、发病12h以内在我院接受急诊介入治疗的患者随机分为2组，分别植入国产药物支架（Firebird支架组，n=78）和金属裸支架（Driver支架组，n=69）。2组年龄、性别、发病时间、病变特征等基础临床情况无显著差异。78支罪犯血管植入Firebird支架83枚，69支罪犯血管植入Driver支架72枚。比较2组住院期和1年随访期的临床转归。结果：2组所用支架长度、内径、术中扩张峰值压力及操作时间无明显差异；术后患者达TIMI3级血流的比例相似。住院期间手术成功率无统计学差异（93％对95％，P〉0．05）。1年随访期内Firebird组与Driver组造影随访率分别为539，6和49％，Driver支架组再狭窄率高于Firebird组（24％对2．5％，P〈0．05），2组均未发生支架内血栓及心源性死亡。结论：国产药物支架对急性ST段抬高型心肌梗死有较好的安全性和临床近、中期疗效。

Clinical use of domestic sirolimus-eluting stents in the treatment of acute ST-elevation myocardial infarction

Objective:To evaluate the safety and effectiveness of domestic sirolimus stent in the acute ST-elevation myocardial infarction. Methods:Among patients with acute ST-elevation myocardial infarction in our hospital from January 2003 to May 2007,a total of 147 patients received emergency PCI within 12 hours of incidence,of which 78 were implanted domestic drug stents (Firebird stent),and 69 received bare metal stent implantation (Driver stent). No significant differences exist between the two groups in terms o...