| 吉非替尼对非小细胞肺癌的疗效与T细胞亚群变化分析 |
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| 引用本文： | 张建波,王祥麒,于庆凯,李璐.吉非替尼对非小细胞肺癌的疗效与T细胞亚群变化分析[J].国外医药(植物药分册),2009(5). |
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| 作者姓名： | 张建波 王祥麒 于庆凯 李璐 |
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| 作者单位： | 河南省肿瘤医院病理科;河南省中医学院第三附属医院肿瘤内科; |
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| 摘 要： | 目的观察吉非替尼治疗晚期非小细胞肺癌(NSCLC)临床疗效与外周T淋巴细胞亚群变化的关系。方法对组织或细胞病理证实的35例晚期NSCLC患者口服吉非替尼250 mg/d。采集全部患者治疗前及治疗后外周血标本,三色染色后流式细胞仪分析CD3+、CD4+、CD8+T淋巴细胞亚群变化。结果35例患者中部分缓解13例,稳定13例,进展9例,疾病控制率为74.2%。治疗前后T淋巴细胞亚群无显著差异。结论吉非替尼治疗晚期非小细胞肺癌疗效较好,毒副反应轻微。治疗后T淋巴细胞可以恢复到治疗前水平。
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| 关 键 词： | 吉非替尼 非小细胞肺癌 T淋巴细胞亚群 |
Analysis of the effects of Gefitinib on patients with advanced non-small cell lung cancer and their T lymphocyte subsets |
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| Authors: | ZHANG Jian-bo WANG Xiang-qi YU Qing-kai LI Lu |
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| Institution: | ZHANG Jian-bo1,WANG Xiang-qi2,YU Qing-kai1,LI Lu1(1.Department of Pathology,Henan Provincial Tumor Hospital,Zhengzhou 450003,China,2.Department of Medical Oncology,The Third Affiliated Hospital of Henan College of Traditional Chinese Medicine,China) |
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| Abstract: | Objective To analyze the effects of Gefitinib on patients with advanced non-small cell lung cancer(NSCLC) and the effect on T lymphocyte subsets.Methods A total of 35 patients with NSCLC confirmed by pathology or cytology administered orally 250 mg of Gefitinib once a day.Three-color fluorescent flow cytometry were used to analyze the percentage of CD3+,CD4+, and CD8+ T lymphocyte in peripheral blood before and after the treatment.Results No complete response(CR) was achieved.At the same time,there were 13 ... |
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| Keywords: | Gefitinib non-small cell lung cancer T lymphocyte subsets |
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