M受体及相关选择性药物研究进展

毒草碱受体（M受体）是体内重要的G蛋白偶联受体之一，有M1～M5五种药理学亚型，各亚型在体内的分布和功能不同，受体蛋白结构和信号转导机制也有差异。对M受体、相关选择性药物及受体一配体作用位点的研究，将为设计以M受体各亚型为靶标的选择性药物提供帮助，对临床治疗多种M受体功能紊乱的疾病，如阿尔茨海默病等具有重要意义。

Muscarinic receptors and related selective drugs: research advances

Muscarinic receptors(M receptors),the important members of G protein-coupled receptors,comprise five subtypes M1-M5.Each subtype has different distribution and biological function in vivo,and their protein structures and signal transduction pathways are distinct as well.Studies on M receptors,related selective drugs and receptor-ligand binding sites could provide some information helpful to the design of selective compounds targeting single M receptor subtype.This is very important to develop clinical thera...