Effect of methylmercury and inorganic mercury on protein synthesis in mammalian cells |
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| Authors: | Susumu Nakada Akio Nomoto Nobumasa Imura |
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| Affiliation: | School of Pharmaceutical Sciences, Kitasato University, 9-1, Shirokane 5-chome, Minato-ku, Tokyo, 108, Japan |
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| Abstract: | Effects of methylmercury and inorganic mercury on protein synthesis in several mammalian cells and cell-free systems were studied. Inorganic mercury showed about a 10 times stronger inhibitory effect on protein synthesis than methylmercury in the cell-free systems prepared from mouse glioma, Yoshida ascites sarcoma cells, and rabbit reticulocytes. Methylmercury inhibited protein in intact cells of Yoshida ascites sarcoma more strongly than inorganic mercury and exerted nearly the same inhibitory effect on protein synthesis in mouse glioma and rabbit reticulocytes as inorganic mercury. |
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| Keywords: | To whom all correspondence should be addressed. |
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