PTEN在膀胱移行细胞癌中的表达及其临床意义

日曲探讨膀胱移行细胞癌中PTEN的表达及其临床意义。方珐应用免疫组织化学（S-P）法对50例膀胱移行细胞癌组织和10例正常膀胱黏膜中PTEN蛋白的表达进行检测。结果膀胱癌组织中PTEN蛋白阳性表达率为54．0％（27／50），明显低于正常膀胱组织100．0％（10／10），两组间的差异有统计学意义（P〈0．01）；且其表达水平在不同病理分级、临床分期间也有显著差异（P〈0．01）。结论PTEN蛋白表达的缺失可能在膀胱移行细胞癌的发生及进展过程中起着重要作用，并影响其生物学行为；检测PTEN蛋白表达水平有助于膀胱癌的诊断和预后判断。

Expression of PTEN in human transitional cell carcinoma of bladder and its clinical significance

Objective To detect the expression of PTEN protein in transitional cell carcinoma of the bladder （TCCB）, and to investigate the relationship between the expression of PTEN and the clinical pathological characteristics of TCCB. Methods A hospital-based case control study was performed on 50 patients with TCCB and 10 normal controls. Immunohistochemistry was used to detect the expression of PTEN protein. Results The positive rate of the expression of PTEN in TCCB was 54.0% （27/50）, obviously lower than that of normal bladder tissue （100.0%, 10/10） （P〈0.01）. It was significantly associated with pathological grade and clinical stage of TCCB （P〈 0.01）. Conclusion PTEN may play an important role in carcinogenesis of TCCB and affect the biological behaviors of it. Detection of its expressions may become a new approach to diagnose TCCB.