| 利用静息态功能磁共振成像研究缺血性脑卒中患者康复治疗后运动功能网络连接的变化 |
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| 引用本文： | 邓小湘,蒋雯,王君,汤启宇,黄瑞旺,张玉梅,艾林,戴建平.利用静息态功能磁共振成像研究缺血性脑卒中患者康复治疗后运动功能网络连接的变化[J].磁共振成像,2010,1(1):11-14. |
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| 作者姓名： | 邓小湘 蒋雯 王君 汤启宇 黄瑞旺 张玉梅 艾林 戴建平 |
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| 作者单位： | 北京师范大学认知神经科学与学习国家重点实验室,100875;首都医科大学附属北京天坛医院影像科,100050;香港理工大学医疗科技及资讯学系;首都医科大学附属北京天坛医院神经内科,100050 |
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| 基金项目： | 国家自然科学基金，教育部留学回国人员科研启动基金 |
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| 摘 要： | 目的利用静息态功能磁共振成像技术研究缺血性脑卒中患者康复治疗前后运动功能网络连接变化的特点。方法对2例符合亚急性缺血性脑卒中影像学诊断标准的患者在功能性电刺激康复治疗前后各进行一次静息态功能磁共振扫描，比较两次扫描的运动脑区功能连接的差异。结果康复后患者上肢运动功能改善；与康复治疗前相比，康复治疗后左侧和右侧的运动皮层功能连接均降低，左侧和右侧的运动皮层功能连接系数降低值与脑卒中患者上肢运动功能以及日常生活能力的改善程度相关。结论缺血性脑卒中患者上肢运动功能改善后，即康复后患侧脑区对健侧脑区依赖性减低，并且功能连接系数的降低与脑卒中患者上肢运动功能的改善相关。
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| 关 键 词： | 缺血性脑卒中 磁共振成像 功能性 静息态 运动皮质 电刺激 康复 |
Investigation of brain motor functional connectivity in ischemic stroke patients after rehabilitative treatment with resting-state functional MRI |
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| DENG xiao-xiang,JIANG Wen,WANG Jun,TANG Qi-yu,HUANG Rui-wang,ZHANG Yu-mei,AI Lin,DAI Jian-ping.Investigation of brain motor functional connectivity in ischemic stroke patients after rehabilitative treatment with resting-state functional MRI[J].Chinese Journal of Magnetic Resonance Imaging,2010,1(1):11-14. |
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| Authors: | DENG xiao-xiang JIANG Wen WANG Jun TANG Qi-yu HUANG Rui-wang ZHANG Yu-mei AI Lin DAI Jian-ping |
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| Institution: | 1.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China ;2.Department of Radiology, Tiantan Hospital of Capital Medical University, Beijing 100050, China; 3.Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China ;4Deparment of Neurology, Tiantan Hospital of Capital Medical University, Beijing 100050, China ) |
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| Abstract: | Objective： To investigate the change of brain motor functional connectivity in ischemic stroke patients after rehabilitative treatment with resting-state functional MRI（fMRI）. Materials and Methods： Resting-state fMRI was employed on two subacute ischemic stroke patients before and after the rehabilitative treatment with functional electric stimulation （FES）, and the difference of brain motor functional connectivity was analyzed. Results： After rehabilitative treatment, motor function of upper extremity was ameliorated, and fimctional connectivity of bilateral motor cortex was decreased. There was the correlation between behavioral improvement and connectivity decrease. Conclusion： The dependence of affected cerebral hemisphere on unaffected cerebral hemisphere was decreased after motor fimctional improvement of upper extremity. |
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| Keywords: | Ischemic stroke Magnetic resonance imaging functional Resting-state Motor cortex Electric stimulation Rehabilitation |
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