435株铜绿假单胞菌的临床分布与耐药性分析

目的了解医院铜绿假单胞菌(PAE)在临床的分布状况和耐药情况,为临床合理选择抗菌药物提供依据。方法对医院2011年1月至2011年12月各种标本分离的PAE用纸片扩散法(K-B)法进行药物敏感性试验,对结果进行统计分析。结果共分离到435株PAE,其中从痰标本中分离出370株,占85.06%;高发病区是神经外科、ICU、呼吸科;其对头孢他啶的耐药性最低,为15.64%,对头孢吡肟、阿米卡星、氨曲南、美罗培南、头孢哌酮舒巴坦的耐药率相对较低,分别为36.25%,36.96%,45.54%,47.89%,48.94%。结论该院PAE的耐药率处于高位,必须加强耐药性监测,为临床提供最新的耐药性资料,医生应合理选用抗菌药物,减少耐药菌株的产生。

Analysis on Clinical Distribution and Drug Resistance in 435 Strains of Pseudomonas Aeruginosa

Objective To investigate the clinical distribution and drug resistance of Pseudomonas aeruginosa（PAE） in hospitals, and to provide the evidence for rational use of antibacterial drugs in clinic. Methods The drug sensitivity test on PAE isolated from various samples collected in our hospital from January to December 2011 was carried out by use of K- B method. Then the results were performed the statistical analysis. Results Four hundred thirty- five strains of PAE were isolated. Of which, 370 strains were isolated from sputum samples, accounting for 85.06%. The high incidence inpatients areas were the departments of neurosurgery, ICU and respi- ration. The resistance to ceftazime was lowest（15.64% ）, the resistances to cefepime, amikacin, aztreonam, meropenem, cefoperazone and sulbactam were relatively lower, which were 36.25% , 36.96%, 45.54%, 47.89% and 48.94% respectively. Conclusion The PAE＇s drug resistance rate in our hospital is on a high position. Therefore, the drug-resistance surveillance and monitoring must be en-hanced to provide the updated information for clinical medication. Doctors should choose antibacterial drugs reasonably to reduce the generation of drug- resistant bacterial strain.