Antihyperglycemic activity of Caralluma tuberculata in streptozotocin-induced diabetic rats |
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| Affiliation: | 1. Clinical Pharmacology Institute, Xiyuan Hospital, China Academy of Chinese Medicine Science, Beijing, 100091, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan Province, 650201, China;3. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, 110016, China;4. Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, 610041, China;1. Departament of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, Brazil;2. Departament of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, Brazil;3. Departament of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, Brazil |
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| Abstract: | ![]()
The current study aimed at evaluating the potential and mechanisms of the antidiabetic activity of the methanolic extract (ME) of Caralluma tuberculata as well as its chloroform (CF), n-butanol (BF) and the remaining water fractions (RFs) in streptozotocin-induced diabetic rats. The antidiabetic activity was evaluated through assessing fasting blood glucose (FBG), insulin levels, oral glucose tolerance test (OGTT), glucose utilization by isolated rat psoas muscle, gut glucose absorption and G-6-Pase activity in isolated rat liver microsomes. Both ME and RF showed the highest potency, where ME had superior activity. The mechanism underlying the observed antihyperglycemic activity of ME could be attributed, at least in part, to enhanced skeletal muscle utilization of glucose, inhibition of hepatic gluconeogenesis and stimulation of insulin secretion. ME was standardized through LC–MS analysis for its major pregnanes. |
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| Keywords: | Antihyperglycemic activity Pregnanes |
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