| 地塞米松在大鼠缺血随意皮瓣中的作用 |
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| 引用本文： | 庄力,徐勇忠,宋业光. 地塞米松在大鼠缺血随意皮瓣中的作用[J]. 中日友好医院学报, 2003, 17(3): 163-165,F004 |
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| 作者姓名： | 庄力 徐勇忠 宋业光 |
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| 作者单位： | 1. 中日友好医院,整形外科,北京,100029
2. 吉林大学口腔医院,颌面外科,吉林长春,130041 |
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| 摘 要： | 目的：研究局部使用地塞米松对大鼠缺血随意皮瓣的作用。方法：建立大鼠背部缺血随意皮瓣的动物模型，随机分为2组，实验组术后皮瓣下一次给予地塞米松5mg(用生理盐水稀释至3ml)，对照组术后皮瓣下一次给予0．9％生理盐水3ml。均于术后7d取材，测定皮瓣坏死率和组织中丙二醛含量，观察大体及病理切片。结果：实验组皮瓣坏死率和丙二醛含量较对照组显著降低(P＜0．01)。光镜下，实验组的炎性反应较对照组明显减轻。结论：地塞米松能提高缺血随意皮瓣的成活率，大剂量一次性给药的方法是可行的。
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| 关 键 词： | 地塞米松 大鼠 生理盐水 丙二醛 皮瓣坏死率 头颈肿瘤 缺血随意皮瓣 再灌注损伤 |
| 文章编号： | 1001-0025(2003)03-0163-03 |
The study of the effect of dexamethasone on the random rat ischemic skin flaps |
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| ZHUANG Li,XU Yong zhong,SONG Ye guang. The study of the effect of dexamethasone on the random rat ischemic skin flaps[J]. Journal of China-Japan Friendship Hospital, 2003, 17(3): 163-165,F004 |
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| Authors: | ZHUANG Li XU Yong zhong SONG Ye guang |
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| Affiliation: | ZHUANG Li,XU Yong zhong,SONG Ye guangDepartment of Plastic Surgery,China Japan Friendship Hospital,Beijing,100029,China |
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| Abstract: | Objective:To investigate the effect of dexamethasone on the random ischemic skin flaps. Methods:The dorsal random skin flaps of Wistar rats were used. After the operations, dexamethasone, at the dose of 25mg/kg, was injected under the flaps. Seven days later, the necrosis rate, the content of malondialdehyde (MDA) and microscopic observation were performed. Results:Compared with that of the control group, the necrosis rate and the content of MDA in the dexamethasone group decreased significantly ( P <0.01).Under the microscope, the tissue inflammatory reactions in the experiment group were not so severe as that of the control group.Conclusion:Dexamethasone could improve the survival of the random ischemic skin flaps and it was applicable to give dexamethasone by subcutaneous injection of one large dose. |
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| Keywords: | skin flap dexamethasone rats |
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