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Thrombotic thrombocytopenic purpura associated with the acquired immune deficiency syndrome |
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| Authors: | Anand Kumar Jean Wang David Sutton Eric J Bow |
| Affiliation: | Section of Critical Care, Department of Medicine, Rush-Presbyterian-St Luke’s Medical Center, Chicago, Illinois, USA; Department of Hematology-Oncology, Toronto Western Hospital, Toronto, Ontario; and Sections of Hematology-Oncology and Infectious Diseases, St Boniface Hospital, Winnipeg, Manitoba |
| Abstract: | A bisexual male presented with acute thrombotic thrombocytopenic purpura (TTP) in association with established acquired immune deficiency syndrome. The patient had classic clinical and laboratory findings of TTP and responded well to plasmapheresis therapy. Previously reported cases of TTP in association with human immunodeficiency virus (HIV) infection are briefly reviewed. Basic concepts in the pathogenesis of TTP are examined in reference to HIV infection. |
| Keywords: | Acquired immune deficiency syndrome Anemia Human immunodeficiency virus Thrombocytopenia Thrombotic microangiopathy Thrombotic thrombocytopenic purpura |