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| 水飞蓟宾磷脂复合物大鼠肠吸收特性 | |
| 引用本文： | 杨秋霞,马福家,张兰兰,陈建明.水飞蓟宾磷脂复合物大鼠肠吸收特性[J].第二军医大学学报,2009,30(11):1288-1291. |
| 作者姓名： | 杨秋霞 马福家 张兰兰 陈建明 |
| 作者单位： | 1. 第二军医大学药学院药剂学教研室,上海,200433 2. 解放军第455医院药剂科,上海,200052 3. 天士力现代中药研究所,天津,300402 |
| 摘 要： | 目的:考察水飞蓟宾磷脂复合物在大鼠全小肠段及各分肠段的吸收。方法:运用大鼠在体肠灌流实验,采用高效液相色谱法测定肠灌流液中药物和酚红的浓度,以吸收百分率和肠壁通透系数为指标,考察水飞蓟宾磷脂复合物的肠吸收特性和肠壁通透性。结果:水飞蓟宾磷脂复合物在小肠中的吸收呈一级动力学特征,6 h时在肠道中约有70%被吸收,吸收速率常数Ka值为(0.193±0.012)h-1;分肠段实验中,各肠段(十二指肠、空肠、回肠、结肠)的吸收百分率和肠壁通透系数均无显著性差异(P>0.05)。结论:水飞蓟宾磷脂复合物在全肠道均有吸收。 |
| 关 键 词： | 水飞蓟宾 磷脂复合物 肠吸收 在体肠灌流 |
| 收稿时间： | 2009/6/15 0:00:00 |
| 修稿时间： | 2009/9/27 0:00:00 |
Absorption characteristics of silybin-phospholipid complex by rat intestine |
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| YANG Qiu-xi,MA Fu-ji,ZHANG Lan-lan,CHEN Jian-ming.Absorption characteristics of silybin-phospholipid complex by rat intestine[J].Academic Journal of Second Military Medical University,2009,30(11):1288-1291. | |
| Authors: | YANG Qiu-xi MA Fu-ji ZHANG Lan-lan CHEN Jian-ming |
| Institution: | YANG Qiu-xia1,MA Fu-jia2,ZHANG Lan-lan3,CHEN Jian-ming11.Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China2.Department of Pharmacy,No.455 Hospital of PLA,Shanghai 2000523.Modern TCM Institute,Tasly Pharmaceutical Co.,Ltd,Tianjin 300402 |
| Abstract: | Objective:To investigate the intestinal absorption of silybin-phospholipid complex by the whole and different segments of rat's intestine.Methods: An in situ intestinal perfusion model was employed in the present research;and absorption percent and intestinal wall permeability coefficient(Ke) were taken as indices.HPLC method was used to determine the concentrations of silybin and phenol red in the perfusate to calculate the absorption indices.Results: The absorption of silybin-phospholipid complex was a fi... |
| Keywords: | silybin phospholipid complex intestinal absorption in situ intestine perfusion |
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