Sister chromatid exchanges in human peripheral blood lymphocytes after ingestion of high doses of arsenicals |
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| Authors: | P. Hantson C. Verellen-Dumoulin J. M. Libouton A. Leonard E. D. Leonard P. Mahieu |
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| Affiliation: | (1) Department of Intensive Care Medicine, Cliniques Universitaires St-Luc, Avenue Hippocrate, 10, B-1200 Brussels, Belgium, BE;(2) Centre for Human and Medical Genetics, Cliniques Universitaires St-Luc, Brussels, Belgium, BE;(3) Laboratory of Teratogenesis and Mutagenesis, Cliniques Universitaires St-Luc, Brussels, Belgium, BE |
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| Abstract: |
Objective
– To evaluate the cytogenetic effects following the ingestion of high doses of arsenicals.
Methods
– Determination of the mean sister chromatid exchange (SCE) frequency and the population of high-frequency cells (HFC, cells
with a high SCE frequency) in the peripheral blood lymphocytes in four patients who ingested 150 mg KAsO2, 1 g, 10 g and 20 g As2O3 respectively.
Results
– Doses of 10 g and 20 g significantly increased the HFC frequency and produced a shift in the distribution of the cells in
accordance with the number of SCEs. The mean frequency of SCEs/cell was affected only after the highest dose (20 g).
Conclusion
– These results strongly suggest that cytogenetic methods are inappropriate for biomonitoring people occupationally exposed
to arsenicals.
Received: 11 December 1995/Accepted 18 January 1996 |
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| Keywords: | Acute arsenic exposure Human peripheral lymphocytes Sister chromatid exchanges |
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