| 免疫组化法检测大肠癌组织p53基因蛋白表达及意义 |
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| 引用本文： | 张文平,张瑞,郭辉,罗静. 免疫组化法检测大肠癌组织p53基因蛋白表达及意义[J]. 山西医科大学学报, 2003, 34(1): 21-22 |
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| 作者姓名： | 张文平 张瑞 郭辉 罗静 |
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| 作者单位： | 1. 山西医科大学公共卫生学院毒理学教研室,太原,030001
2. 山西医科大学第二医院消化内科 |
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| 摘 要： | 目的：研究大肠癌组织中抑癌基因p53基因的表达及意义。方法：手术切除42例大肠癌组织用免疫组化技术检测p53蛋白表达。结果：p53基因蛋白表达与大肠癌患者肿瘤大小，浸润深度及Dukes 分期无明显关系。P53基因蛋白表达阳性患者淋巴结转移率高。结论：p53基因蛋白表达阳性患者肿瘤易发生转换且患者预后差。
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| 关 键 词： | 免疫组织化学 大肠肿瘤 p53基因 基因表达 临床意义 |
| 文章编号： | 1007-6611(2003)01-0021-02 |
| 修稿时间： | 2002-11-11 |
Significance of measurement of p53 gene protein in colorectal cancer by immunohistochemical method |
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| ZHANG Wen ping,ZHANG Rui,GUO Hui,et al. Significance of measurement of p53 gene protein in colorectal cancer by immunohistochemical method[J]. Journal of Shanxi Medical University, 2003, 34(1): 21-22 |
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| Authors: | ZHANG Wen ping ZHANG Rui GUO Hui et al |
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| Abstract: | Objective To study the significance of tumor suppression gene p53 gene in colorectal carcinoma. Methods Forty two patients with colorectal carcinoma underwent surgical resection. ABC immunohistochemical staining was used to detect the expression of p53 gene proteins. Results There were no obvious correlations between p53 expression and infiltrationsize and depth, and Dukes staging. Twenty two patients were p53 positive, in which 14 was accompanied with lymph node metastasis, while only 5 had lymph node metastasis in 20 patients with p53 negative. Conclusion The p53 gene overexpression is mainly related to the prognosis and is easy for tumor to metastasize. |
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| Keywords: | colorectal neoplasms genes p53 immunohistochemistry |
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