Therapeutic effect of antimicrobial drugs against experimental infections due toYersinia pestis in mice |
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Authors: | Sachiko Goto Akiyoshi Tsuji Teiko Murai Minoru Nishida Hiroko Tsukano Haruo Watanabe |
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Institution: | (1) Division of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan;(2) College of Health Profession, Toho University, 4-16-20 Omori-nishi, Ota-ku, 143-0015 Tokyo, Japan |
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Abstract: | Although there are effective antibacterial agents against plague, newer antibacterial agents have been developed which show
more potent activity against other bacterial organisms, but have not been tested againstYersinia pestis. A strain ofYersinia pestis was selected (no. 22; National Institute of Infectious Diseases, Tokyo, Japan) that caused a systemic infection in mice.Y. pestis no. 22 was intraperitoneally inoculated into DDY-strain mice, and 13 oral or 6 injectable antibacterial drugs given to the
infected mice at varying doses 1 and 24 hours after infection. Levofloxacin, sparfloxacin and ofloxacin were the most effective
oral agents against the infection, and prulifloxacin and pazufloxacin were also effective but to a lesser extent. Also, gentamicin
and arbekacin were the most potent injectable antibacterial agents againstY. pestis. These results suggest that there are several new drugs, both oral and injectable, which exert excellent in vivo antibacterial
activity against a mouse infection model and may be useful for the clinical treatment of plague. |
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Keywords: | Yersinia pestis in vivo effect antimicrobials experimental infection model |
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