补肾法对犬心肌缺血模型一氧化氮、内皮素的影响

目的观察补肾法对犬心肌缺血模型血清一氧化氮(NO)、内皮素(ET)的作用。方法将20只心肌缺血模型犬随机分为模型组、空白对照组、阳性对照组及补肾法组。补肾法组用补肾中药治疗,阳性对照组用单硝酸异山梨酯治疗作为对照,观察服药前后血NO、ET的情况。结果补肾中药治疗后,犬心肌缺血模型血清NO明显升高、ET明显下降,与单硝酸异山梨酯组比较有显著性差异(P<0.05,P<0.01)。结论补肾法能够明显提高血清NO、降低ET,这可能是其治疗动脉粥样硬化引起的缺血性疾病的机理之一。

Effect of Therapy of Tonifying the Kidney on Serum NO and ET in Myocardial Ischemia Dog

Objective To observe the effect of the therapy of tonifying the kidney on plasma NO and ET in dog with myocardial ischemia. Methods 20 dogs of myocarclial ischemia were divided into the model group control group, isosorbide mononitrate group and the therapy of tonifying the kidney group by random. The NO and ET of serum were measured before and after treatment. Results The level of NO was higher and the level of ET was lower than that of the isosorbide mononitrate group. There was significant difference between the control group and the therapy of tonifying the kidney group (P <0.05, P <0.01). Conclusion The therapy of Tonifying the kidney can increase serum NO and inhibit ET. That might be one of anti-ischemia mechanism of the therapy of tonifying the kidney.