The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice

Conclusions The findings presented in this report show that: (1) 5-lipoxygenase inhibitors and some leukotriene antagonists protect the gastric mucosa against lesions induced by oral or parenteral administration of most NSAIDs, with the possibility of some variation in effects with aspirin.(2) These observations suggest that overproduction of leukotrienes and other products of 5-lipoxygenase activity may play a role in the development of acute gastric mucosal damage induced by NSAIDs.