抗性淀粉对氧化偶氮甲烷诱导大鼠结(直)肠癌过程中肠道功能及变性隐窝病灶的影响

目的  研究抗性淀粉（RS）对结(直)肠癌大鼠的肠道功能及变性隐窝病灶（ACF）的影响。方法  将50只雄性Wistar大鼠随机分为阴性、阳性对照组及RS低、中、高剂量组。阳性对照组大鼠从实验第2周开始腹腔注射氧化偶氮甲烷（AOM），每周1次，连续2周。阴性对照组注射生理盐水。RS各剂量组致癌剂处理同阳性对照组，并分别自由摄食含7.6%、15.2%及22.8%RS的饲料。阴性和阳性对照组大鼠摄食普通饲料。实验期间每周称重1次，于第5周末和第7周末分别进行粪便pH及排便实验。第16周断头处死所有大鼠，取出结肠组织进行指标ACF的测定。结果  与阳性对照组相比，RS各剂量组ACF数目、肠道转运时间（GTT）均明显减少（P＜0.01），粪便pH也有所下降（P＜0.05），差异有统计学意义。结论  RS有利于肠道内的环境健康，降低ACF的发生，可能是预防结(直)肠癌发生的机制之一。

Effects of resistant starch on intestinal function and aberrant crypt foci during the development of rat colorectal cancer induced by Azoxymethane

Objective To study the effect of resistant starch (RS) on intestinal function and aberrant crypt foci (ACF) for colorectal cancer in rats. Methods A total of 50 male Wistar rats were randomly divided into 5 groups: the negative control group,the positive control group and three different RS added groups (RS concentration was 7. 6% ,15. 2% and 22. 8% ). Rats in the positive control group were subcutaneously injected with azoxymethane (AOM) once a week in the second and third weeks. Rats in the negative contr...