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| 重复测量统计分析方法在抑郁症患者生命质量研究中的应用 | |
| 引用本文： | 陈卓蕾,陈兴宝. 重复测量统计分析方法在抑郁症患者生命质量研究中的应用[J]. 复旦学报(医学版), 2007, 34(3): 396-399 |
| 作者姓名： | 陈卓蕾 陈兴宝 |
| 作者单位： | 复旦大学公共卫生学院卫生经济教研室,上海,200032;复旦大学公共卫生学院卫生经济教研室,上海,200032 |
| 基金项目： | 致谢 本研究样本资料的收集和随访来自于下列合作单位（排名不分先后）：复旦大学附属中山医院、同济大学附属同济医院、上海市第一人民医院、上海第二医科大学附属瑞金医院和新华医院、上海市第十人民医院（原铁路中心医院）、虹口精神卫生中心. |
| 摘 要： | 目的探讨重复测量统计分析方法在抑郁症患者生命质量研究中的应用。方法用重复测量方差分析法研究抑郁症患者在不同时点的生命质量变化。结果单变量重复测量方差分析结果显示,在治疗后3个月、6个月时生命质量各个指标和总分与基线相比均有显著变化,并呈现线性趋势。多变量重复测量方差分析结果显示,疾病因素（不同临床表现患者）与时间因素的交互作用对生命质量的影响有统计学意义。结论重复测量在生命质量的研究中不仅能够说明各观测值随时间的变化趋势,并且能通过交互作用的意义来说明分组因素的作用是否会随着时间发生变化。 |
| 关 键 词： | 抑郁症 生命质量 重复测量 |
| 修稿时间： | 2006-10-10 |
Application of the method of repetitive measure in analysis of quality of life in depressed outpatients |
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| CHEN Zhuo-lei,CHEN Xing-bao. Application of the method of repetitive measure in analysis of quality of life in depressed outpatients[J]. Fudan University Journal of Medical Sciences, 2007, 34(3): 396-399 | |
| Authors: | CHEN Zhuo-lei CHEN Xing-bao |
| Affiliation: | Department of Health Economics, School of Public Health, Fudan University, Shanghai 200032, China |
| Abstract: | Purpose The aim of this study was to discuss the application of repetitive measure in a-nalysis of quality of life (QOL) in depressed outpatients. Methods Repetitive measure analysis of variance (ANOVA) was used in analyzing QOL at different time points. Results The QOL measured at baseline, 3 months and 6 months increased significantly by uni-variate test of repetitive measure ANOVA. The effect of interaction between disease and time was statistically significant on QOL by multi-variate test of repetitive measure ANOVA. Conclusions Repetitive measure in analysis of QOL can not only demonstrate the change in QOL and its time trend, but also explain the degree of change with time for the QOL in different groups by interaction meaning. |
| Keywords: | depression quality of life (QOL) repetitive measure |
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