Avidity of IgG antibodies against mumps, parainfluenza 2 and Newcastle disease viruses after mumps infection |
| |
| Authors: | O P Lehtonen O H Meurman |
| |
| Affiliation: | 1. Departments of Medical Microbiology University of Turku, Turku, Finland;2. Departments of Virology, University of Turku, Turku, Finland;1. Department of Pediatrics, Division of Neonatology and Pediatric Hematology/Oncology, Chang Gung Memorial Hospital, Yunlin, Taiwan;2. Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi, Taiwan;3. Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi, Taiwan;4. Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chia-Yi, Taiwan;5. Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan;6. Center for Drug Abuse and Addiction, China Medical University Hospital, China Medical University, Taichung, Taiwan;7. Division of Neurosurgery, Department of Surgery, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan;8. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;9. Department of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan;10. Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan;1. Department of Physics, Saurashtra University, Rajkot 360005, India;2. H & H.B. Kotak Institute of Science, Rajkot 360001, India;3. Human Resource Development Center, Saurashtra University, Rajkot 360005, India;4. Inter University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi 110067, India;1. Graduate Institute of Health Industry Technology, Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan, Taiwan;2. Department of Pulmonary Infection and Immunology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan;3. School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan;4. Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242, Taiwan;5. School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;6. International MS/PhD Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;7. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;1. SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 440-746, Republic of Korea;2. Center for Human Interface Nanotechnology (HINT), Sungkyunkwan University, Suwon 440-746, Republic of Korea;3. Department of Phisics, Sungkyunkwan University, Suwon 440-746, Republic of Korea;4. College of Information and Communication Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea;1. Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;2. Department of Chemistry, Razi University, Kermanshah, Iran;3. Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran;4. School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Iran;5. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran;1. Key Lab of RF Circuits and Systems of the Ministry of Education, College of Electronics and Information, Hangzhou Dianzi University, Hangzhou 310018, China;2. Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education & International Center for Dielectric Research, Xi’an Jiaotong University, Xi’an 710049, China;3. Department of Applied Chemistry, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Science, Xi’an Jiaotong University, Xi’an 710049, China |
| |
| Abstract: | ![]()
Paired serum samples from 39 patients with recent mumps infection were assayed for IgG antibodies against mumps, parainfluenza 2 and Newcastle disease virus (NDV). A modified enzyme immunoassay was used, giving separate estimates of high avidity antibodies (EHAA) and total specific antibodies (ETSA). A marked cross-reaction was seen between mumps and parainfluenza 2 virus, with changes of ETSA between paired samples of about the same magnitude against both these viruses. The mean change of EHAA against mumps was, however, significantly greater than that against parainfluenza 2. There were 16 patients who had a change of ETSA greater against parainfluenza 2 than against mumps. When the EHAA responses were compared, there were only 8 such patients. The responses against NDV were negligible. Estimation of antibody avidity, even by the arbitrary method used, can distinguish between homotypic and cross-reactive heterotypic antibodies after mumps infection. The implications for expressing the results of enzyme immunoassay are discussed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
