| 中心型肺癌快速旋转调强与固定射野动态调强放疗的剂量学比较 |
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| 引用本文： | 弓健,余荣,吴昊,韩树奎,徐博,朱广迎,蒋璠.中心型肺癌快速旋转调强与固定射野动态调强放疗的剂量学比较[J].中华放射医学与防护杂志,2010,30(4):448-451. |
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| 作者姓名： | 弓健 余荣 吴昊 韩树奎 徐博 朱广迎 蒋璠 |
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| 作者单位： | 暨北京市肿瘤防治研究所放疗科,恶性肿瘤发病机制及转化研究教育部重点实验室,北京大学临床肿瘤学院北京肿瘤医院,100142 |
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| 摘 要： | 目的 比较快速旋转调强(RapidArc)与固定射野动态调强(dIMRT)两种调强放疗技术在中心型肺癌治疗计划中的剂量学差异。方法 利用瓦里安(Varian)计划系统(Eclipse 8.6)随机选取10例已行dIMRT治疗的中心型肺癌患者,采用容积调强(volumetric modulated arc therapy,VMAT)治疗技术设计RapidArc调强放疗计划。在满足靶区处方剂量要求(95%体积的PTV达到66 Gy)的情况下,通过剂量体积直方图DVH评价和比较两种类型治疗计划的PTV最大剂量 Dmax、最小剂量 D min和平均剂量 Dmean以及适形指数CI,危及器官的脊髓最大剂量 D max,双肺的 V5、V 10、 V20、 V30,心脏 V30,食管 V50、V60和平均剂量 Dmean,并比较两种治疗计划的总机器跳数(MU)和治疗时间。结果 在中心型肺癌治疗计划中,与dIMRT相比较,RapidArc靶区的 D max、 Dmin和 Dmean略有升高,但统计学差异无意义( P >0.05), 适形指数CI优于dIMRT,且差异具有统计学意义(t=-4.968,P=0.001)。双肺的 V5、V10有所上升, V20、 V30有所下降;心脏 V30受照射体积也有不同程度降低,差异均具有统计学意义。RapidArc总MU减少32%,治疗时间为dIMRT的1/3。结论 两种治疗技术所设计的治疗计划剂量分布均能满足临床治疗需要。RapidArc靶区适形度更高,实际治疗时间明显缩短,同时MU的降低减少了治疗区域正常组织的不必要照射。
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| 关 键 词： | 快速旋转调强 动态调强 中心型肺癌 剂量学 |
| 收稿时间： | 2010/3/13 0:00:00 |
Dosimetric comparison between RapidArc and fixed gantry dynamic IMRT for central-type lung cancer radiotherapy |
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| GONG Jian,YU Rong,WU Hao,HAN Shu-kui,XU Bo,ZHU Guang-ying and JIANG Fan.Dosimetric comparison between RapidArc and fixed gantry dynamic IMRT for central-type lung cancer radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2010,30(4):448-451. |
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| Authors: | GONG Jian YU Rong WU Hao HAN Shu-kui XU Bo ZHU Guang-ying and JIANG Fan |
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| Institution: | Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, School of Oncology, Peking University, Beijing Cancer Hospital & Institute, Beijing 100142, China;Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, School of Oncology, Peking University, Beijing Cancer Hospital & Institute, Beijing 100142, China;Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, School of Oncology, Peking University, Beijing Cancer Hospital & Institute, Beijing 100142, China;Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, School of Oncology, Peking University, Beijing Cancer Hospital & Institute, Beijing 100142, China;Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, School of Oncology, Peking University, Beijing Cancer Hospital & Institute, Beijing 100142, China;Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, School of Oncology, Peking University, Beijing Cancer Hospital & Institute, Beijing 100142, China;Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiation Oncology, School of Oncology, Peking University, Beijing Cancer Hospital & Institute, Beijing 100142, China |
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| Abstract: | |
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| Keywords: | RapidArc Dynamic intensity modulated radiation therapy Central-type lung cancer Dosimetry |
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