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目的了解湖州地区儿童牙齿内铅含量,以及稳定的生活环境下齿铅负荷对儿童生长发育的影响因素。方法湖州市妇幼保健院等于2002年6月至2004年12月采用整群抽取湖州城市、农村共10所幼儿园,检测了在园就读171例儿童离体乳牙(上门齿)铅的含量,以ROC曲线法确定高齿铅值。结果高齿铅的临界值为19·50μg/g,儿童体格发育指标与齿铅(对数转换后)的相关分析发现,高齿铅量与儿童的身高呈负相关关系(r=-0·370,P<0·001),差异有极显著的统计学意义,与体重、头围的相关性检验无统计学意义。以齿铅为自变量,采取逐步法进行多元线性回归模型拟合,发现齿铅含量与儿童注意力、身高、母亲职业等8个因素在方程中具有统计学意义(F=10·312,P<0·01)。结论母亲职业铅接触、易拉罐食品、婴幼儿啃指甲动作、营养素失衡均是导致儿童体内铅负荷增高的主要因素,而高齿铅对儿童身高的影响最大。

A research on teeth lead and its effects on children's growth

?? AbstractObjectiveTo understand the relationship between lead load and its effects on children's growth in this area by measuring the lead content with teeth lead as reference sample. MethodsSamples collected by Huzhou Matemal and Children Care Hosital between June 2002 and February 2004 were randomly selected from 10 urban and rural kindergartens in Huzhou area,and teeth lead content in deciduous teeth (up incisor) analyzed among 171 children;ROC method was used to identify the high threshold of teeth lead level. ResultsThe high threshold of teeth lead was 19.50??g /g;by analyzing the correlation between growth index and teeth lead concentration (logarithmic conversion),it is shown that there was a reciprocal relationship between high threshold of teeth lead and height (r=-0.370??P<0.01) with statistical significance,and no statistical relationship between high threshold of teeth lead and weight or head size.With teeth lead as a variant,a progressive modeling of multiple??linear regression was adopted to show that teeth lead had statistical significance on eight factors such as children??s attention,height and professions of mothers (F=10.312 P<0.01). ConclusionLead contamination from mother's profession,canned food,nail??gnawing habit and nutritional deficiency are the main factors to contribute to the increase of lead concentration of children in this area.