Treatment of muscle spasticity in patients with cerebral palsy using BTX-A: a pilot study |
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Authors: | Felipe Scalco Manzano DDSc Lucia Mercuri Granero MD Danilo Masiero MD Maria Teresa Botti Rodrigues dos Santos DDSc PhD |
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Affiliation: | Dental Unit, Lar Escola São Francisco, São Paulo, Universidade Cruzeiro do Sul, São Paulo.;Universidade Federal de São Paulo, Universidade Cruzeiro do Sul, São Paulo.;Division of Dentistry for Persons with Disabilities, Universidade Cruzeiro do Sul, São Paulo. |
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Abstract: | This study was designed to verify the safety and efficacy of botulinum toxin type A (BTX-A) used as a neuromuscular block on spastic masticatory musculature of children with cerebral palsy. Six patients who had spastic-tetraplegic cerebral-palsy, aged 5 to 20 years were selected. All patients had spasticity of the jaw muscles, bruxism, lower lip trauma, limited mouth opening, and difficulties in cleaning the oral cavity. The patients were sedated under general anesthesia, while the dentist injected the masseter and temporalis muscles bilaterally with 150 and 75 units of BTX-A each. Clinical examinations were conducted at 7, 14, 30, and 90 days after the initial appointment. We found statistically significant decreases in muscle spasticity and bruxism ( p = 0.002), improved inter-incisal opening ( p = 0.002), improved oral hygiene ( p = 0.031), and less lower lip trauma ( p = 0.060) after the neuromuscular blocking. |
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Keywords: | cerebral palsy spasticity botulinum toxin bruxism |
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