| 沙利度胺调节多发性骨髓瘤共刺激分子表达的研究 |
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| 引用本文： | 杨云,张王刚,何爱丽,杨惠云,汪瑛,田玮.沙利度胺调节多发性骨髓瘤共刺激分子表达的研究[J].南方医科大学学报,2009,29(12):2470-2472,2476. |
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| 作者姓名： | 杨云 张王刚 何爱丽 杨惠云 汪瑛 田玮 |
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| 作者单位： | 1. 西安交通大学医学院第二附属医院血液科,陕西,西安,710004
2. 西安外国语大学医院,陕西,西安,710004 |
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| 摘 要： | 目的探讨B7共刺激分子在人类多发性骨髓瘤细胞上的表达及沙利度胺对其表达的调节作用。方法通过细胞培养研究沙利度胺对人骨髓瘤细胞系B7.1分子表达的调节作用,用流式细胞仪检测B7分子的表达。结果人类多发性骨髓瘤细胞系及患者骨髓瘤细胞缺乏B7.1分子的表达,阳性细胞百分比分别为0.8及2.19±2.13,B7.2分子的表达分别为26.4及30.28±28.11。与阴性对照组相比,除0.1μg/ml组外,随着沙利度胺浓度的增加,CD80分子表达的阳性细胞百分比明显提高（P〈0.01）,5μg/ml浓度组为（17.7±1.53）%,达到最高。结论多发性骨髓瘤细胞不表达或低表达B7.1分子,上调B7.1分子的表达可能是沙利度胺治疗多发性骨髓瘤有效的机制之一。
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| 关 键 词： | 多发性骨髓瘤 沙利度胺 B7共刺激分子 肿瘤免疫 |
Regulatory effect of thalidomide on the expression of constimulatory molecules in patients with multiple myeloma |
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| YANG Yun,ZHANG Wang-gang,HE Ai-li,YANG Hui-yun,WANG Ying,TIAN Wei.Regulatory effect of thalidomide on the expression of constimulatory molecules in patients with multiple myeloma[J].Journal of Southern Medical University,2009,29(12):2470-2472,2476. |
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| Authors: | YANG Yun ZHANG Wang-gang HE Ai-li YANG Hui-yun WANG Ying TIAN Wei |
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| Institution: | YANG Yun1,ZHANG Wang-gang1,HE Ai-li1,YANG Hui-yun1,WANG Ying2,TIAN Wei1 1Department of Hematology,Second Affiliated Hospital of Xi'an Jiaotong University College of Medcine,Xi'an,China,2Xi'an International Studies University,Xi'an 710004 |
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| Abstract: | Objective To investigate the expression of B7 co-stimulatory molecules in human multiple myeloma (MM) and the immunoregulatory effects of thalidomide on B7.1 co-stimulator. Methods The immunoregulatory effects of thalidomide on the expression of B7-1 in human MM cell line was examined by detecting the changes in the expression of B7 co-stimulator on the cells using flow cytometry following the drug treatment. Results The expression of B7.1 co-stimulator was lowly expressed in human MM cell line and MM patie... |
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| Keywords: | multiple myeloma thalidomide B7 constimulatory molecules tumor immunity |
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