|
|||||
|
|
| 口腔疣状癌基质金属蛋白酶-2、基质金属蛋白酶-9和金属蛋白酶组织抑制因子-2的表达及其相关性的研究 | |
| 引用本文： | 赵鑫,曹雷,张璐. 口腔疣状癌基质金属蛋白酶-2、基质金属蛋白酶-9和金属蛋白酶组织抑制因子-2的表达及其相关性的研究[J]. 实用医学杂志, 2010, 26(2). DOI: 10.3969/j.issn.1006-5725.2010.02.010 |
| 作者姓名： | 赵鑫 曹雷 张璐 |
| 作者单位： | 1. 113-8549,东京医科齿科大学齿学部口腔病理研究室 2. 大连大学医学院口腔医学系,116021 |
| 摘 要： | 目的:研究口腔疣状癌中基质金属蛋白酶(MMP)-2、MMP-9及金属蛋白酶组织抑制因子(TIMP-2)的表达.探讨其在口腔疣状癌发生发展过程中的作用和意义.方法:取25例口腔疣状癌,10例正常口腔黏膜,25例口腔鳞癌(高、低分化鳞癌各为15、10例),应用免疫组织化学法检测上述标本中MMP-2、MMP-9及,TIMP-2的表达和分布.结果:正常口腔黏膜组织TIMP-2为阴性表达:MMP-2、MMP-9的阳性表达率分别为10.00%、20.00%.口腔疣状癌MMP-2阳性表达率为28.00%.MMP-9阳性表达率为44.00%,TIMP-2阳性表达率为72.00%.口腔疣状癌、口腔高分化鳞癌、口腔低分化鳞癌MMP-2、MMP-9、TIMP-2表达均高于正常口腔黏膜(P<0.05).结论:在口腔疣状癌,口腔高分化鳞癌、口腔低分化鳞癌中.MMP-2与MMP-9的阳性表达率呈正相关,与TIMP-2呈负相关;相关分析发现,MMP-2、MMP-9和TIMP-2的袁达两两相关,同时3者的表达可能单独或共同参与. |
| 关 键 词： | 癌,疣状 基质金属蛋白酶-2 基质金属蛋白酶-9 金属蛋白酶组织抑制因子-2 |
Matrix metalloproteinase-2,matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-2 expression and their correlations in oral verrucous carcinoma |
|
| ZHAO Xin,CAO Lei,ZHANG Lu. Matrix metalloproteinase-2,matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-2 expression and their correlations in oral verrucous carcinoma[J]. The Journal of Practical Medicine, 2010, 26(2). DOI: 10.3969/j.issn.1006-5725.2010.02.010 | |
| Authors: | ZHAO Xin CAO Lei ZHANG Lu |
| Affiliation: | ZHAO Xin,CAO Lei,ZHANG Lu. OralPathology Laboratory,Faculty of Dentistry,Tokyo Medical , Dental University,Tokyo 113-8549,Japan |
| Abstract: | Objective To investigate of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9(MMP-9) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) expression and their correlations in oral verrucouscarcinoma (OVC). Methods 25 cases of OVC, 10 cases of normal oralmucosa (NM),15 cases of well differentiatedsquamous cell carcinoma (wdSCC), 10 cases of poorly differentiated squamous cell carcinoma (pdSCC) specimens wereused for MMP-2, MMP-9 and TIMP-2 detection by immunohistochemistry S-P method. Res... |
| Keywords: | Carcinoma verrucous Matrix metalloproteinase-2 Matrix metalloproteinase-9 Tissueinhibitor metalloproteionase-2 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |