| 多西紫杉醇治疗晚期乳腺癌的临床观察 |
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| 引用本文： | 龙明辉,程小跃. 多西紫杉醇治疗晚期乳腺癌的临床观察[J]. 中国药房, 2008, 19(29): 2286-2287 |
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| 作者姓名： | 龙明辉 程小跃 |
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| 作者单位： | 湖南省肿瘤医院药剂科,长沙市,410006 |
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| 摘 要： | 目的:观察多西紫杉醇(TXT)对晚期乳腺癌的疗效、安全性、剂量限制性毒性(DLT)和最大耐受剂量(MTD)。方法:TXT按剂量递增分为65、75、85mg.m-2。第1天静脉滴注,剂量递增至出现DLT。结果:15例患者中,完全缓解1例,部分缓解5例,稳定4例,进展5例。TXT的DLT为中性粒细胞减少,MTD为85mg.m-2。结论:TXT75mg.m-2治疗晚期乳腺癌疗效显著,耐受性良好。
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| 关 键 词： | 多西紫杉醇 乳腺癌 最大耐受剂量 |
Clinical Observation of Efficacy of Docetaxel in the Treatment of Advanced Breast Cancer |
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| LONG Ming-hui,CHENG Xiao-yue. Clinical Observation of Efficacy of Docetaxel in the Treatment of Advanced Breast Cancer[J]. China Pharmacy, 2008, 19(29): 2286-2287 |
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| Authors: | LONG Ming-hui CHENG Xiao-yue |
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| Affiliation: | (Dept. of Pharmacy, Hunan Provincial Tumor Hospital, Changsha 410006, China) |
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| Abstract: | OBJECTIVE： To observe the clinical efficacy, safety, the maximal tolerated dose （MTD） and dose- limiting toxicity （DLT） of docetaxel （TXT） in the treatment advanced breast cancer. METHODS： Doeetaxel was given by drip infusion in escalating doses from the initial dose of 65 mg·m^-2 to 75 mg ·m^-2 and 85 mg·m^-2 until the appearance of DLT. RESULTS： Among the 15 cases, i case with CR, 5 PR, 4 SD, and 5 PD. The DLT of TXT was neutropenia, and its MTD was 85 mg·m^-2. CONCLUSION： Docetaxel （at a dose of 75 mg ·m^-2） showed remarkable efficacy and good tolerance in patietns with advanced breast cancer. |
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| Keywords: | Docetaxel Breast cancer Maximum tolerated dose |
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