| 评估血管内皮细胞生长因子及其受体在大鼠大脑中动脉短暂闭塞再灌注后对缺血脑组织的保护作用 |
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| 引用本文： | 徐冰.评估血管内皮细胞生长因子及其受体在大鼠大脑中动脉短暂闭塞再灌注后对缺血脑组织的保护作用[J].中国组织工程研究与临床康复,2002,6(1):52-53. |
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| 作者姓名： | 徐冰 |
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| 作者单位： | 沈阳市第一人民医院,辽宁沈阳110042 |
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| 摘 要： | 目的研究血管内皮细胞生长因子(VEGF)及其受体Flt-1在大鼠短暂大脑中动脉闭塞(MCAO)再灌注后不同时点表达的变化,探讨VEGF对缺血脑组织的保护作用。方法采用栓线法MCAO动物模型,通过免疫组化方法观察VEGF及Flt-1的表达情况。结果VEGF及FIt-1免疫阳性细胞主要在神经元、神经胶质细胞及内皮细胞中表达。结论这些发现表明短暂MCAO后VEGF及Flt-1的表达上调,提示可能VEGF及Flt-1表达的增加对促进缺血周边区血供的恢复有重要作用。
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| 关 键 词： | 血管内皮细胞生长因子 Flt-1 大脑中动脉闭塞 免疫组化 |
| 文章编号： | 1671-5926(2002)01-0052-02 |
| 修稿时间： | 2001年12月14 |
Investigate cerebral protect effect of the VEGF gene and its receptor Flt-1 after transient cerebral ischemia |
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| XU Bing.First People Hopital of Shenyang ,China.Investigate cerebral protect effect of the VEGF gene and its receptor Flt-1 after transient cerebral ischemia[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2002,6(1):52-53. |
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| Authors: | XU BingFirst People Hopital of Shenyang China |
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| Institution: | XU Bing.First People Hopital of Shenyang 110042,China |
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| Abstract: | Objective To investigate the induction of VEGF gene and his receptor Flt-1 expression after transient focal cerebral ischemia at protein levels in order to clarify the role of VEGF in cerebral ischemia.Method A transient middle cerebral artery (MCA) occlusion model was used.Cellular changes of VEGF and its receptor Flt-1 expression were compared with immunohistochemitry.Result VEGF gene and its receptor Flt-1 expressed in the neurons, glial cells and vascular endothelial.Conclusion VEGF and Flt-1 are upregulated during the early period after transient MCAO in the rat. This indicated that the increasing expression of VEGF and Flt-1 possibly had affection to recover the blood supply in the border region. |
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| Keywords: | VEGF Flt-1 MCAO immunohistochemitry |
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