三黄口服液治疗代谢综合征的疗效观察

目的:探讨三黄口服液对代谢综合征肥胖人群的临床疗效。方法:以20名健康志愿者为参照,将100名代谢综合征患者随机分为治疗组(60名)和安慰剂组(40名),分别予三黄口服液和安慰剂治疗12周,观察治疗前后患者心血管危险因素的变化。结果:与安慰剂组相比,治疗组(起效剂量为10 ml/人,黄连素浓度为0.16～0.22 mg/ml)除空腹血糖,甘油三酯在治疗前后无显著差异外,腰围、体质量指数、腰臀围比值、胰岛素抵抗指数,血清C反应蛋白水平、游离脂肪酸明显改善,差异有显著性(P<0.05);随着腰围的增大,男性的糖代谢异常、高血压病、血脂紊乱及代谢综合征的发生率均呈现增高趋势(P<0.01)。结论:三黄口服液可明显降低代谢综合征人群肥胖和胰岛素抵抗程度,并能改善炎症状态,减轻致心血管病的危险性。

Clinical study of San-Huang Decoction in treating metabolic syndrome men

Objective: To study the therapeutic effects of San-Huang Decoction,a Chinese medicine preparation,on metabolic syndrome men.Methods: Compared with 20 healthy male volunteers,100 metabolic syndrome men were separated randomly into two groups and received the interventions with San-Huang Decoction and placebo respectively for 12 weeks.Baseline characteristics,insulin resistance and inflammation cytokines were evaluated before and after treatment.Results: After treatment,compared with placebo group,body mass index,waist,and waist-to-hip ratio,insulin resistance,C-reactive protein,free fatty acid were decreased significantly in subjects who received San-Huang decoction(P < 0.05),while fasting blood glucose and triglyceride hardly changed.With the increase of waist circumference,the incidence of abnormal glucose metabolism,hypertension,dyslipidemia and metabolic syndrome showed an increasing tendency(P < 0.01).Conclusion: San-Huang can reduce insulin resistance in metabolic syndrome men and improve inflammation and fibrinolysis,which indicates that it can reduce the risk of cardiovascular disease.