血氧水平依赖功能磁共振评价脑肿瘤恶性程度与脑皮层功能区距离和激活体积的相关性

目的 利用血氧水平依赖功能磁共振(BOLD-fMRI)评价脑肿瘤恶性程度与脑皮层功能区距离和激活体积的相关性.资料与方法 33例经手术病理证实的位于或邻近中央前回的脑肿瘤患者,包括恶性肿瘤组16例和良性肿瘤组17例,术前采用对指模式的组块(BLOCK)刺激方法,应用BOLD-fMRI成像技术,分析良恶性肿瘤与脑功能区边缘的距离及激活体积的相关性.结果 恶性肿瘤组BOLD激活体积为(31.29±10.87),良性肿瘤组BOLD激活体积为( 79.53±16.27),差异有统计学意义(P＜0.05);良性肿瘤组肿瘤边缘距脑皮层运动功能区距离平均(5.65±2.29) mm,恶性肿瘤组肿瘤边缘距脑皮层运动功能区距离平均(5.00±2.76) mm;恶性肿瘤组肿瘤至脑皮层功能区的距离与激活体积比呈正相关(R2=0.407,P＜0.01),良性肿瘤组肿瘤至脑皮层功能区的距离与激活体积比呈正相关(R2=0.25,P＜0.05),恶性肿瘤组较良性肿瘤组肿瘤至脑皮层功能区的距离与激活体积比的相关性更加显著.结论 脑肿瘤对周围脑组织产生影响,影响运动激活区状态,且在恶性肿瘤中更明显.

The Correlation Between the Grade of Brain Tumors with the Distance and Activation Volume in Brain Motor Cortex on BOLD-fMRI

Purpose To evaluate the correlation between the grade of brain tumors with the distance and activation volume in brain motor cortex on blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI).Materials and Methods Thirty-three patients with brain tumors locating or adjacent to the motor cortex were studied,pre-operation using finger-tapping paradigm with BOLDfMR imaging.The influence of the different distance between the tumors and the brain motor cortex on the activation volume was analyzed,and the correlativity between them was also evaluated.Results The activation volume in malignant tumors group activation volume was (31.29±10.87),the activation volume in benign tumors group activation volume was (79.53±16.27);the distance of benign tumors group to the brain motor cortex was (5.65±2.29) mm,the distance of malignant tumors group to the brain motor cortex was (5.00±2.76) mm;the activation volume in benign tumors group was more than the malignant.The activation volume showed markedly significant correlation with the distance of malignant tumors group to the brain motor cortex (R 2 =0.407,P <0.01),and the activation volume also showed significant correlation with the distance of benign tumors group to the brain motor cortex (R 2 =0.25,P<0.05).Conclusion The malignant and benign brain tumors can influence the brain motor cortex activation volume,and it is more significant in malignant tumors.