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| 二氢杨梅素对醛糖还原酶的抑制作用 | |
| 引用本文： | 刘恺,高丽辉,牛艳芬,袁丽仙,刘旭,李玲. 二氢杨梅素对醛糖还原酶的抑制作用[J]. 中药药理与临床, 2012, 0(4): 43-45 |
| 作者姓名： | 刘恺 高丽辉 牛艳芬 袁丽仙 刘旭 李玲 |
| 作者单位： | 昆明医学院生物医学工程研究中心 |
| 基金项目： | 国家自然科学基金资助项目(30760306);云南省应用基础研究计划重点项目(2006C009Z) |
| 摘 要： | 目的:研究二氢杨梅素体外对醛糖还原酶(AR)的影响。方法:取正常SD大鼠晶状体制备醛糖还原酶,以依帕司他1×10-7mol/L为阳性对照,观察二氢杨梅素1.0×10-5、4.0×10-5、1.4×10-4、6.4×10-4mol/L四个浓度体外对醛糖还原酶的抑制作用。结果:随着二氢杨梅素浓度的增加,醛糖还原酶的活性逐渐降低,且呈一定的剂量-效应关系,在终浓度为6.4×10-4mol/L时,其对醛糖还原酶活性的抑制率为54.3%。结论:二氢杨梅素在体外有抑制醛糖还原酶的作用。 |
| 关 键 词： | 醛糖还原酶 二氢杨梅素 糖尿病 |
Inhibitory effect of dihydromyricetin on aldose reductase activity |
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| Liu Kai,Gao Lihui,Niu Yanfen,YanLixian,LiuXu,LiLing. Inhibitory effect of dihydromyricetin on aldose reductase activity[J]. Pharmacology and Clinics of Chinese Materia Medica, 2012, 0(4): 43-45 | |
| Authors: | Liu Kai Gao Lihui Niu Yanfen YanLixian LiuXu LiLing |
| Affiliation: | (Biomedical Engineering Research Center,Kunming Medical University,Kunming 650500) |
| Abstract: | Objective: To study the effect of dihydromyricetin on the activity of aldose reductase(AR) in vitro.Methods: Aldose reductase was extracted from lens of normal SD rat.Epalretat(1×10-7 mol/L) was as a positive.The inhibitory effects of dihydromyricetin,at a concentration of 1.0×10-5,4.0×10-5,1.4×10-4 and 6.4×10-4 mol/L,on the activity of aldose reductase were investigated in vitro.Results: Dihydromyricetin markedly inhibited the activity of aldose reductase,in a concentration-dependent manner,with the inhibitory ratio of 54.3% at the concentration of 6.4×10-4 mol/L.Conclusion: Dihydromyricetin has the inhibitory activity on aldose reductase in vitro. |
| Keywords: | dihydromyricetin(二氢杨梅素) aldose reductase diabetes |
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