巨噬细胞在种植体骨结合及早期失败的研究进展

随着现代化医疗技术的完善和发展,种植牙成功率已经越来越高.然而,种植失败仍有发生,早期失败则在其中占了很大的比重.异物反应是宿主识别外来植入物发生的免疫反应,然而过度异物反应引起的纤维包封以及种植体表面的腐蚀则会阻碍骨结合,导致种植体早期失败.作为参与异物反应的主要免疫细胞,巨噬细胞可以在不同的刺激下被诱导分化成M1型...

Research progress on the role of macrophages in implant osseointegration and early failure

With the improvement and development of medical technology,the success rate of dental implant has become higher than before.However,implant failure still occurs from time to time,in which the early failure accounts for a large proportion.The implant itself as a foreign body,might provoke host immune response characterized as foreign body reaction.However,fiber encapsulation caused by excessive foreign body reaction and implant surface erosion can inhibit osseointegration,leading to early implant failure.As the most abundant cells in foreign body reaction,the activated macrophages are capable of polarizing to two mainly specific phenotypes with pro-inflammatory(M1)or anti-inflammatory(M2)by stimulation,which can not only regulate foreign body reaction but also affect bone tissue homeostasis.In this paper,the role of macrophages in osseointegration,fibrosis and foreign body giant cell formation will be expounded,aiming to guiding the clinical practice and reducing the early failure by regulating the biological behaviors of macrophages.