儿童轻度缺铁性贫血间歇补铁疗法的有效性研究北大核心CSCD

目的研究间歇性补铁疗法治疗儿童轻度缺铁性贫血的临床疗效。方法前瞻性选取147例轻度缺铁性贫血患儿分为间歇补铁组(n=83)和常规补铁组(n=64),检测两组患儿治疗前、治疗1个月后和治疗3个月后血红蛋白水平,对两组的治疗有效率及不良反应发生率进行统计分析。结果经过补铁治疗后,常规补铁组和间歇补铁组血红蛋白水平均较治疗前升高(P<0.05)。治疗1个月后,常规补铁组治疗有效率(61%)高于间歇补铁组(42%)(P<0.05)。治疗3个月后,常规补铁组治疗有效率(86%)与间歇补铁组(78%)比较差异无统计学意义(P>0.05)。常规补铁组的不良反应发生率(25%)高于间歇补铁组(8%)(P<0.05)。结论虽然间歇补铁法对轻度缺铁性贫血患儿的短期疗效不及常规补铁法,但是长期疗效无差异;而且相对于常规补铁法,间歇补铁法可降低不良反应发生率,减轻家庭经济负担,提高患儿治疗依从性,值得临床推广应用。

Efficacy of intermittent iron supplementation in children with mild iron-deficiency anemia

Objective To study the efficacy of intermittent iron supplementation in children with mild irondeficiency anemia.Methods A total of 147 children with mild iron-deficiency anemia were enrolled in this prospective study.They were divided into an intermittent iron supplementation group(n=83)and a conventional iron supplementation group(n=64).The levels of hemoglobin were measured before treatment and after 1 and 3 months of treatment.The treat response rate and the incidence rate of adverse drug reactions were compared between the two groups.Results Both groups had a significant increase in the level of hemoglobin after iron supplementation(P<0.05).After 1 month of treatment,the conventional iron supplementation group had a significantly higher treatment response rate than the intermittent iron supplementation group(61%vs 42%,P<0.05).After 3 months of treatment,there was no significant difference in the treatment response between the two groups(86%vs 78%,P>0.05).The incidence rate of adverse drug reactions in the conventional iron supplementation group was significantly higher than that in the intermittent iron supplementation group(25%vs 8%,P<0.05).Conclusions For children with mild iron-deficiency anemia,although intermittent iron supplementation is inferior to conventional iron supplementation in the short-term efficacy,there is no significant difference in the long-term efficacy between the two methods,and compared with conventional iron supplementation,intermittent iron supplementation can reduce the incidence of adverse drug reactions,alleviate family financial burdens,and improve treatment compliance of children,thus holding promise for clinical application.