非酒精性脂肪性肝病在心血管疾病发生发展中的作用

随着经济水平的提高、饮食结构和生活方式的改变,非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的发病率不断上升,逐渐成为全球慢性肝病的主要病因.心血管疾病(cardiovascular disease,CVD)作为NAFLD患者的主要死亡原因,越来越多的研究发现两者之间存在相关性;NAFLD患者CVD发生发展的风险更大,其机制可能与血管和内皮细胞功能障碍、胆汁酸代谢、氧化应激、全身炎症反应和肾素-血管紧张素系统的激活等相关.其中,代谢综合征在两者联系中发挥了重要的作用.因此,早期识别NAFLD患者心血管疾病相关危险因素,进而减少心血管相关并发症,对于改善该类患者的预后至关重要.

Role of non-alcoholic fatty liver disease in development of cardiovascular disease

With the improvement of the economic level and changes in dietary structure and lifestyle,the incidence of non-alcoholic fatty liver disease(NAFLD)has been increasing.It has gradually become the main cause of chronic liver diseases in the world.Cardiovascular disease(CVD)is the main cause of death in NAFLD patients,and more and more studies have found that there is a correlation between the two conditions.NAFLD patients are at greater risk of developing CVD than normal patients.Associated mechanisms may be related to dysfunction of blood vessels and endothelial cells,bile acid metabolism,oxidative stress,systemic inflammation,and activation of the renin-angiotensin system.Among them,metabolic syndrome plays an important role.Therefore,early identification of cardiovascular disease-related risk factors in NAFLD patients and thereby reducing cardiovascular-related complications are essential to improve the prognosis of those patients.