Synthesis, crystal structure, and anticancer properties of cyclic monocarbonyl analogs of curcumin |
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| Authors: | Natesan Sundarmurthy Karthikeyan Kulathu Iyer Sathiyanarayanan Paduthapillai Gopal Aravindan P. Giridharan |
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| Affiliation: | (1) Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632 014, India;(2) Physics Division, School of Advanced Sciences, VIT University, Vellore, 632 014, India;(3) Piramal Life Sciences Ltd., Mumbai, 400 063, India; |
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| Abstract: | ![]()
A series of novel indan-2-one and dibenzylidenepiperidin-4-one compounds were synthesized and screened for anticancer activities. The compounds are symmetrical and they have conjugated double bonds. They closely resemble the curcumin analogs which are found to possess anticancer properties. The structure of the compounds was confirmed by single crystal study and wherever the compound is a powder, the structures were confirmed by spectral data (IR, NMR, and Mass). |
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