Effects of CYP3A4*1G and CYP3A5*3 polymorphisms on pharmacokinetics of tylerdipine hydrochloride in healthy Chinese subjects |
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| Authors: | Sufeng Zhou Mingxue Tao Yuanyuan Wang Lu Wang Lijun Xie Juan Chen |
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| Affiliation: | 1. Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;2. Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China |
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| Abstract: | The aim of this analysis was to explore the influence of CYP3A4*1G and CYP3A5*3 polymorphisms on the pharmacokinetics of tylerdipine in healthy Chinese subjects. A total of 64 and 63 healthy Chinese subjects were included and identified as the genotypes of CYP3A4*1G and CYP3A5*3, respectively. Plasma samples were collected for up to 120?h post-dose to characterize the pharmacokinetic profile following single oral dose of the drug (5, 15, 20, 25 and 30?mg). Plasma levels were measured by a high-performance liquid chromatography-mass spectrometry (LC-MS/MS). The pharmacokinetic parameters were calculated using non-compartmental method. The maximum concentration (Cmax) and the area under the curve (AUC0–24?h) were all corrected by the dose given. In the wild-type group, the mean dose-corrected AUC0–24?h was 1.35-fold larger than in CYP3A4*1G carriers (p?=?.018). Among the three CYP3A5 genotypes, there showed significantly difference (p?=?.008) in the t1/2, but no significant difference was observed for the AUC0–24?h and Cmax. In subjects with the CYP3A5*3/*3 genotype, the mean t1/2 was 1.35-fold higher than in CYP3A5*1/*1 group (p?=?.007). And the t1/2 in CYP3A5*3 carriers also was 1.32-fold higher than in the wild-type group (p?=?.004). CYP3A4*1G and CYP3A5*3 polymorphisms may influence tylerdipine pharmacokinetic in healthy Chinese subjects.
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| Keywords: | Tylerdipine hydrochloride pharmacokinetics CYP3A4*1G CYP3A5*3 polymorphism healthy Chinese subjects |
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