Growth fractions of breast cancer in relation to epidermal growth factor receptor and estrogen receptor |
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Authors: | Masakazu Toi MD Tsutomu Wada Hirofumi Yamada Akihiko Ohsaki Atsushi Yamamoto Takashi Nakamura Minoru Nimoto Takao Hattori |
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Institution: | (1) The Department of Surgery, Research Institute for Nuclear Medicine and Biology, Hiroshima University, Kasumi, 1-2-3, Minami-ku, 734 Hiroshima, Japan |
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Abstract: | Growth fractions detected by a monoclonal antibody, Ki-67, were examined in 40 human breast cancer tissues and the results
compared with the immunocytochemical reactivities of epidermal growth factor receptor (EGFR) and estrogen receptor (ER). The
proportion of proliferating cells displaying Ki-67 positive staining was significantly higher in the EGFR positive tumors
than in the EGFR negative tumors (p<0.01). The average percentage of Ki-67 positive cells in the EGFR positive tumors was
19.9 per cent, whereas that in the EGFR negative tumors was 8.0 per cent. By contrast, an inverse relationship between the
proportion of proliferating cells and ER positive cells detected by anti-ER monoclonal antibody was observed. This data indicated
the difference in growth fractions with relation to the EGFR and ER status of breast cancer. |
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Keywords: | growth fraction breast cancer EGF receptor Ki-67 |
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