地氯雷他定联合卡介菌多糖核酸对慢性荨麻疹疗效观察

目的:对比抗组胺药地氯雷他定联用免疫调节剂卡介菌多糖核酸与单用抗组胺药治疗慢性荨麻疹的效果.方法:将门诊收治的慢性荨麻疹患者随机分为对照组和试验组,对照组单用地氯雷他定,试验组则给予地氯雷他定联用免疫调节剂卡介茵多糖核酸,治疗4周后进行疗效评估,4月后进行远期复发评估对比.结果:经过4周的治疗后,对照组的总有效率为62.5％,治疗组总有效率为84.6％,组间差异有统计学意义(p＜0.01).治疗4个月后的随访结果显示对照组治疗后4月的复发率为47.3％ (30/64),但对照组的同期复发率仅为8.9％ (11/123),两组间复发率存在显著差异(p＜0.01).结论:地氯雷他定联合卡介菌多糖核酸治疗CU安全、有效,两药联用后疗效比单用地氯雷他定得到了显著的改善.

The Clinical Observation on Loratadine Combined with BCG-PSN on Chronic Urticaria

Objective: To compare the antihistamine loratadine in conjunction with immunomodulators BCG-PSN and the effect of antihistamine treatment of chronic urticaria(cu).Method: Patient with chronic urticaria were randomly divided into control and experimental group and control group sites loratadine alone,the experiment group were given desloratadine combined with BCG-PSN for 4 weeks.Efficacy assessment were taken after 4 months of long-term relapse in follow-up.Result: After 4 weeks of treatment,the control group,the total effective rate was 62.5% and 84.6% in control group and experiment group,difference between the groups was statistically significant(P<0.01).4 months after treatment follow-up results in the control group after 4 months 47.3% recurrence rate(30/64),but the relapse rate over the same period the control group was 8.9%(11/123),the recurrence rate between the two groups there significant difference(P<0.01).Conclusion: Loratadine combined BCG-PSN in treatment of CU is safe and effective.