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| 青藤碱对RBL-2H3肥大细胞增殖凋亡以及活化脱颗粒的影响 | |
| 引用本文： | 王文君,李红,杜群,王培训,梁瑞燕. 青藤碱对RBL-2H3肥大细胞增殖凋亡以及活化脱颗粒的影响[J]. 免疫学杂志, 2009, 25(3) |
| 作者姓名： | 王文君 李红 杜群 王培训 梁瑞燕 |
| 作者单位： | 广州中医药大学免疫研究室 |
| 摘 要： | 目的 通过研究青藤碱对肥大细胞增殖凋亡以及活化脱颗粒的影响,深入探讨青藤碱的抗炎作用机理.方法 应用细胞培养,流式细胞术等方法,观察青藤碱等药物对体外培养的RBL-2H3肥大细胞增殖凋亡以及活化脱颗粒的影响.结果 青藤碱对肥大细胞增殖有明显的抑制作用,其IG50约为1 mmol/L,并能促进肥大细胞凋亡,且对RBL-2H3肥大细胞活化脱颗粒有较强的抑制作用.结论青藤碱可能部分通过下调肥大细胞功能发挥抗炎抗风湿作用. |
| 关 键 词： | 青藤碱 RBL-2H3肥大细胞 增殖 凋亡 脱颗粒 |
Effects of Sinomenine on proliferation and degranulation in RBL-2H3 mast cells |
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| WANG Wenjun,LI Hong,DU Qun,WANG Peixun,LIANG Ruiyan. Effects of Sinomenine on proliferation and degranulation in RBL-2H3 mast cells[J]. Immunological Journal, 2009, 25(3) | |
| Authors: | WANG Wenjun LI Hong DU Qun WANG Peixun LIANG Ruiyan |
| Affiliation: | WANG Wenjun,LI Hong,DU Qun,WANG Peixun,LIANG Ruiyan Department of Immunology,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China |
| Abstract: | Objective To explore the anti-inflammatory mechanisms of Sinomenine,a pure alkaloid extracted from Chinese medical plant Sinomenium acutum. Methods RBL-2H3 mast cells were cultured in vitro to observe the effects of Sinomenine on cell proliferation,apoptosis,and degranulation. Results Sinomenine could obviously inhibit the proliferation and the antigen-induced degranulation in RBL-2H3 mast cells,but promote the apoptosis of RBL-2H3 mast cells. Conclusion The anti-inflammatory effects of Sinomenine may parti... |
| Keywords: | Sinomenine RBL-2H3 mast cells proliferation apoptosis degranulation |
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