乳酸左氧氟沙星体外抗菌作用研究

乳酸左氧氟沙星（ｌｅｖｏｆｌｏｘａｃｉｎ ｌａｃｔａｅ）具有对革兰氏阳性菌，阴性菌抗菌作用强的特点。从临床分离的３０２株细菌敏感试验结果显示，该药对金葡萄球菌甚为敏感，其ＭＩＣ５０为０．０６ｍｇ／ＬＭ，ＭＩＣ９０为０．２５ｍｇ／Ｌ，ＭＢＣ５０为０．０６ｍｇ／Ｌ，ＭＢＣ９０为０．５ｍｇ／Ｌ，与日产左氧氟沙星基本一致，较氟沙星强。

In vitro antibacterial activity of levofloxacin lactate

Levofloxacin lactate has a broad spectrum and a potent activity against both Gram positive and Gram negative bacteria. The in vitro antibacterial activity of levofloxacin lactate aganist 302 clinical bacterial isolates showed: levofloxacin lactate had good activities against S.aureus the MIC 50 and MIC 90 of S.aureus were 0.06 and 0.25 mg/L, MBC 50 and MBC 90 were 0.06 and 0.5 mg/L. It also had good activities against Salmonella , the MIC 50 and MIC 90 of Salmonella were 0.03 and 0.25 mg/L. MBC 50 and MBC 90 were 0.03 and 0.25 mg/L respectively. The antibacterial activities were comparable to those of imported levofloxacin and higher than that of ofloxacin. The activity of levofloxacin lactate was unaffected or a little affectd by the inoculum size and adding of serum.But the activity of levofloxacin lactate was higher in the alkaline medium.