炮制对芫花毒性和药效的影响

芫花为毒性较强的中药，为保证临床用药安全有效，须炮制后供用。本文探讨炮制对芫花毒性和药效的影响。结果表明：醋炙品毒性较小，利尿作用较强。芫花素及其模拟醋炙品均有镇咳祛痰作用，作用强度二者无显著差异。芫花酯甲及其模拟醋炙品１∶１×１０^－５～１×１０^－６浓度均可引起离体子宫及肠管收缩，但二者作用强度未见明显差异。对未孕大鼠及妊娠子宫作用比较，妊娠大鼠子宫更敏感。

Effects of Processing on Toxicity and Pharmacological Action of Flos Genkwa

Daphne genkwa can not be taken unless the toxicity is removed. The study on the effect of processing on the toxicity and pharmacological action of Flos Genkwa has shown that the toxicity of vinegar-processed Flos Genkwa is lower than that of the rude drug, but the pharmacological action is better. Both genkwanin and its vinegar-processed imitation have antitussive and expectorant actions without marked difference in efficacy. Both yuanhuacine and its vinegar-processed imitation could cause contraction of the extracorporeal womb and the intestinal canal, and the efficacy is almost similar in the concentration of 1:10(-5)-10(-6). The gestational womb was observed more sensitive than the normal one.