口腔扁平苔藓724例的回顾性分析

目的对口腔扁平苔藓（oral lichen planus，OLP）的临床及病理学特点进行大样本量的研究。方法对上海交通大学医学院附属第九人民医院·口腔医学院口腔黏膜科1978年1月至2006年10月的存档病例进行筛选，选出临床及病理诊断为OLP且半年内至少复诊1次的病例共724例，记录病例的性别、年龄、部位、类型、家族史、病理活检、随访时间、是否癌变及系统性疾病史，并对病例资料进行统计学分析。结果本组OLP病例的随访时间从1个月到259个月（平均随访时间为21个月）。在724例患者中，68．23％是女性，31．77％是男性。OLP的累及部位依次为颊部、舌背、舌腹、唇部、牙龈、腭部、口底。在原发的病损类型中，大部分为斑纹型，占总数的53．82％。病损发生在两个部位以上的OLP患者占总数的48．76％。15例发生了癌变，癌变率为2．07％。结论OLP具有癌变潜能，长时间及规律的随访对于监控OLP的恶性转变过程至关重要。

Oral lichen planus: a retrospective study of 724 Chinese patients

OBJECTIVE: To retrospectively analyze oral lichen planus (OLP) patients and to summarize the clinical characteristic of OLP in Chinese patients. METHODS: A total of 724 patients with histologically and clinically confirmed OLP were collected from department of oral mucosa in School of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University between 1978 and 2006. RESULTS: The OLP patients were followed up from 1 month to 259 months (mean 21 months). Of the 724 patients, 68.23% were women and 31.77% were men. The buccal mucosa was the most common site of involvement in each form, followed by the dorsal tongue, ventral tongue, lip, gingiva, palate and the floor of mouth. The reticular form of the disease was the predominant type in 53.82% of patients at initial presentation. About 48.76% of the patients had multiple oral sites of involvement. Fifteen OLP lesions developed into carcinoma, the malignant transformation rate was 2.07%. CONCLUSIONS: Because OLP has potential of malignant change, a long time and periodical follow-up is of great importance for detection of malignant lesions.