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| 丹酚酸A抗肝细胞过氧化损伤对肝星状细胞增殖的影响 | |
| 引用本文： | 刘成,胡义扬,王润平,刘成海,刘平. 丹酚酸A抗肝细胞过氧化损伤对肝星状细胞增殖的影响[J]. 中国中西医结合消化杂志, 2001, 9(1): 15-16 |
| 作者姓名： | 刘成 胡义扬 王润平 刘成海 刘平 |
| 作者单位： | 上海市中医药大学肝病研究所, |
| 基金项目： | 上海市教委曙光计划资助项目(No.95SG26) |
| 摘 要： | 目的：观察丹酚酸A（SA－A）抗肝细胞过氧化损伤时在抑制肝星状细胞（HSC）增殖中的作用。方法：以不同浓度的丙二醛（MDA）刺激HSC，通过氚标胸腺嘧啶（^3H[TdR]）掺入法，观察对HSC增殖作用，以及SA－A对损伤肝细胞MDA含量及促HSC增殖的影响。结果：一定浓度的MDA有促进HSC增殖的作用；损伤肝细胞MDA含量明显增加；SA－A可抑制损伤肝细胞对HSC的促增殖作用，并可降低损伤肝细胞MDA的含量。结论：SA－A可通过抗肝细胞过氧化损伤抑制HSC的增殖。 |
| 关 键 词： | 肝损伤 丹酚酸A 脂质过氧化 丙二醛 肝星状细胞 |
Effects of SalvianolicAcid-A on Proliferation of HSC |
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| LIU Cheng,HU Yiyang,WANG Runping,et al Institute of Liver Diseases,Shanghai University of TCM,Shanghai. Effects of SalvianolicAcid-A on Proliferation of HSC[J]. Chinese Journal of Integrated Traditional and Western Medicine on Digestion, 2001, 9(1): 15-16 | |
| Authors: | LIU Cheng HU Yiyang WANG Runping et al Institute of Liver Diseases Shanghai University of TCM Shanghai |
| Affiliation: | LIU Cheng,HU Yiyang,WANG Runping,et al Institute of Liver Diseases,Shanghai University of TCM,Shanghai 200032 |
| Abstract: | Objective:The inhibiting action of Salvianolic Acid A on proliferation of HSC was observed under the conditions of antiperoxide injury.Methods:HSC was stimulated by different concentration MDA.The proliferation of HSC was assayed by 3H incorporation.At the same time the effects of Salvianolic Acid A on the content of MDA in injured hepatocyte were observed.Results:Certain concentration MDA could promote the proliferation of HSC.The content of MDA was increased in injured hepatocyte. Salvianolic Acid A could inhibit the promoting action of HSC proliferation induced by injured hepatocyte and reduce the content of MDA in injured hepatocyte.Conclusion:Salvianolic Acid A can inhibit the proliferation of HSC by antiperoxide injury of hepatocyte. |
| Keywords: | Liver injury Salvianolic Acid A Lipid peroxidation Malonyldialdehyde Hepatic stellate cell |
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