| 牛磺酸对肝细胞质膜脂质过氧化的影响 |
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| 引用本文： | 陈岳祥 张灵芝. 牛磺酸对肝细胞质膜脂质过氧化的影响[J]. 医学争鸣, 1992, 13(4): 279-281 |
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| 作者姓名： | 陈岳祥 张灵芝 |
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| 作者单位： | 唐都医院消化内科(陈岳祥，王慎传，赵国宁)，北京医科大学心肺内分泌研究室(张灵芝，汤健)，北京医科大学心肺内分泌研究室(唐朝枢) |
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| 摘 要： | ![]()
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| 关 键 词： | 牛磺酸 过氧化脂质 肝细胞质膜 |
Effect of taurine on lipid peroxidation of isolated rat hepatocellular plasma membrane |
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| CHEN Yue-Xiang WANG Shen-Chuan ZHAO Guo-Ning ZHANG Ling-Zhi TANGJian and TANG Chao-Shu. Effect of taurine on lipid peroxidation of isolated rat hepatocellular plasma membrane[J]. Negative, 1992, 13(4): 279-281 |
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| Authors: | CHEN Yue-Xiang WANG Shen-Chuan ZHAO Guo-Ning ZHANG Ling-Zhi TANGJian and TANG Chao-Shu |
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| Affiliation: | CHEN Yue-Xiang WANG Shen-Chuan ZHAO Guo-Ning ZHANG Ling-Zhi TANGJian and TANG Chao-ShuDepartment of Gastroenterology,Tangdu HospitalLaboratory of Cardiopulmonary Endocrinology,Beijing Medical University |
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| Abstract: | ![]()
In order to investigate the mechanism of the protective effect of taurine on hepatocytes, authors observed the effect of taurine on lipid peroxidation (LPO ) induced by generating system of free radicals (GSFR) in isolated rat hepatocyte membranes. It was found that taurine could inhibited in vitro LPO formation of hepatocyte plasma membranes induced by GSFR in dose- and time-dependant manner: 5, 10, 20 mmol/L taurine inhibited malon dialdehyde (MDA) formation by 10.6%, 45.8% (P<0.01) and 59.6% (P<0.01), respectively; 5, 10, 15 min after incubation with 20 mmol/L taurine, MDA content also decreased by 33.5%, 59.6% and 68.7% (P<0.01). The result indicated that the anti-lipid peroxidation effect of taurine is one of the most important mechanisms of its protective action. |
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| Keywords: | taurine lipid peroxidation hepatocellular plasma membrane |
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