自身免疫性疾病患者血清抗弓形虫抗体调查

目的 了解自身免疫性疾病患者弓形虫感染情况,为后续有针对性地开展弓形虫病防治工作提供依据.方法 以237例自身免疫性疾病确诊患者作为调查对象,其中系统性红斑狼疮患者79例、类风湿性关节炎患者71例、炎症性肠病患者87例,以237例健康志愿者作为对照.采用酶联免疫吸附试验检测自身免疫性疾病患者和健康对照者血清抗弓形虫Ig...

Seroprevalence of Toxoplasma gondii infections among patients with autoimmune diseases

Objective　To understand the seroprevalence of Toxoplasma gondii infections among patients with autoimmune diseases, so as to provide the scientific evidence for the management of toxoplasmosis in patients with autoimmune diseases. Methods　A total of 237 patients with definitive diagnosis of autoimmune disease were selected as the study subjects, including 79 cases with systemic lupus erythematosus, 71 cases with rheumatoid arthritis and 87 cases with inflammatory bowel disease, while 237 healthy volunteers served as controls. The serum anti⁃T. gondii IgG antibody was detected using enzyme⁃linked immunosorbent assay (ELISA) in patients with autoimmune diseases and healthy controls, and the detection of serum IgG antibody against T. gondii was compared between the autoimmune disease patients and healthy controls. Results　The seroprevalence of serum IgG antibody against T. gondii was significantly greater in patients with autoimmune diseases than in healthy controls (29.96% vs. 4.22%; [χ2] = 55.41, P < 0.01), and the seroprevalence of T. gondii infection was all significantly higher in patients with systemic lupus erythematosus (31.65%), rheumatoid arthritis (23.94%) and inflammatory bowel disease (33.33%) than in healthy controls ([χ2] = 45.25, 26.58 and 50.95; all P values < 0.01). Conclusion　The seroprevalence of anti⁃T. gondii IgG antibody is significantly higher in patients with autoimmune diseases than in healthy controls, and T. gondii infection may be a potential risk factor for the development of systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease.