血管通透性因子在声带息肉中的表达

目的:研究血管通透性因子(VPF)在声带息肉中的表达,进一步探讨声带息肉的发病机制。方法:应用免疫组织化学SP染色法检测VPF在37例声带息肉及11例正常人声带中的表达,并对其阳性表达结果进行比较。结果:VPF在声带息肉中表达阳性率51.35%,与正常人声带阳性表达率18.18%相比差异无统计学意义(P>0.05)。而VPF在声带息肉固有层中血管阳性数百分率(56.66±25.48)%高于正常声带的(37.11±29.52)%(P<0.05)。组织阳性表达率及血管阳性数百分率均差异无统计学意义(均P>0.05)。结论:VPF对声带息肉发生过程中组织极度水肿的产生可能有非常重要的作用,参与声带息肉的形成和发展。控制细胞因子VPF在声带息肉中的产生,可能为声带息肉的治疗找到新的方法。

Expression of vascular permeability factor in human vocal cord polyps

OBJECTIVE: This study aimed to analyse the expression of vascular permeability factor (VPF) in human vocal fold polyps. Meanwhile, we studied the pathogenesis of vocal cord polyp further. METHOD: The expression of VPF were detected with immunohistochemical staining in the 37 cases with vocal cord polyps and 11 healthy vocal folds tissues (SP method). Meanwhile,the positive results were contrasted. RESULT: The percent of positive expression of VPF was 51.35 in vocal cord polyps. This expression tended not to be increased greatly compared with the percent of positive expression of VPF (18.18%) in healthy vocal fold (P > 0.05). But,the percent of positive vascular counts of VPF in the vocal cord polyps (56.66 +/- 25.48) %was higher than that in the healthy vocal fold tissues (37.11 +/- 29.52)% (P < 0.05). In the vocal cord polyps , there was no significant difference in the expression of VPF between the male and female( P > 0.05). CONCLUSION: The VPF may play a key role in the formation of heavy edema of vocal cord polyps. The VPF may be involved in the formation and development of vocal cord polyps . If we can control the produce of VPF in the vocal cord polyps, we may find a new way to treat it.