| 神经性厌食的事件相关电位P300的实验研究 |
| |
| 引用本文： | 刘强,陈珏,楼翡璎,杨程青,陈兴时,肖泽萍. 神经性厌食的事件相关电位P300的实验研究[J]. 上海精神医学, 2010, 22(3): 144-146 |
| |
| 作者姓名： | 刘强 陈珏 楼翡璎 杨程青 陈兴时 肖泽萍 |
| |
| 作者单位： | 上海交通大学医学院附属精神卫生中心,200030 |
| |
| 基金项目： | 上海市卫生局青年科研基金 |
| |
| 摘 要： | 目的研究神经性厌食（AN）患者的事件相关电位P300特点。方法应用Nicolet Bravo脑电生理仪,采用纯音＂Oddball＂刺激诱发模式,对43例AN患者和34名健康对照进行认知性电位P300检测。结果 AN组P300中靶P3的潜伏期[（297.8±29.3）ms]长于健康对照组[（285.6±19.7）ms],差异有统计学意义（t=2.19,P=0.03）;AN组靶P3波幅为（6.5±3.4）μV,低于健康对照组（9.8±3.2）μV,差异有统计学意义（t=4.33,P〈0.01）。2组的靶P2、靶N2及非靶P2的潜伏期、波幅均无统计学差异。结论 AN患者的P300靶P3潜伏期延长、波幅降低。
|
| 关 键 词： | 神经性厌食 事件相关电位 P300 |
Experimental study of P300 in anorexia nervosa |
| |
| Liu Qiang,Chen Jue,Lou Feiying,Yang Chengqing,Chen Xingshi,Xiao Zeping. Experimental study of P300 in anorexia nervosa[J]. Shanghai Archives of Psychiatry, 2010, 22(3): 144-146 |
| |
| Authors: | Liu Qiang Chen Jue Lou Feiying Yang Chengqing Chen Xingshi Xiao Zeping |
| |
| Affiliation: | .Shanghai Mental Health Center(Shanghai Jiaotong University School of Medicine,Shanghai 200030 ) |
| |
| Abstract: | Objective：To investigate the characteristics of P300 in patients with anorexia nervosa （AN）.Methods：P300 were recorded in 43 AN patients and 34 healthy controls by the standard oddball paradigm presented with auditory double clicks stimuli,using Nicolet Bravo instrument.Results：Compared with control group,AN group showed significantly prolonged latency of target P3 （t=2.19,P=0.03） and significantly decreased amplitude of target P3 （t=4.33,P0.01）.There were no significant difference in the latencies and amplitudes of target P2,target N2 and non-target P2 between the two groups.Conclusion：AN Patients were characterized with prolonged latency and decreased amplitude of target P3 in the P300,supporting the hypothesis that they might have cognitive impairment. |
| |
| Keywords: | P300 |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
